Rapid Fire Abstracts
Simon Rösel, BA
Medical Student
University Hospital Göttingen, Germany
Sören Backhaus, MD
Consultant Cardiologist
Department of Cardiology, Heart Centre, Kerckhoff-Clinic Bad Nauheim, Germany
Torben Lange, MD
Resident
University Medical Center Göttingen, Germany, Germany
Alexander Schulz, MD
Dr.
Harvard Medical School / BIDMC, Germany
Johannes Kowallick, MD
Prof.
University Medical Center Göttingen, Germany, Germany
Kritika Gowda, MD
Research Assistant
Taussig Heart Center
Julia Treiber, MD
senior physician
Kerckhoff Klinik, Germany
Andreas Rolf, MD
Senior Cardiologist
Kerckhoff Klinikum Bad Nauheim, Germany
Samuel Sossalla, MD
chief medical officer
Kerckhoff Klinik, Germany
Gerd Hasenfuß, MD
Prof
University Medical Center Göttingen, Germany, Germany
Shelby Kutty, MD
Dr.
Taussig Heart Center, USA
Andreas Schuster, MD, PhD
Cardiologist
University Medical Center Göttingen, Germany
Pulmonary stenosis (PS) is common in congenital heart disease and an integral finding in Tetralogy of Fallot (TOF). Pulmonary regurgitation (PR) is more commonly found following surgery in repaired TOF. We aimed to evaluate the haemodynamic effects of PS and PR on cardiac physiology in a porcine model using cardiac magnetic resonance-based feature tracking (CMR-FT) deformation imaging.
Methods:
CMR-FT was performed in 14 pigs before and 10-12 weeks after surgery. Surgery included either pulmonary artery banding to simulate PS (n=7), or an incision to the pulmonary valve to simulate PR (n=7). CMR-FT assessment included left and right ventricular global longitudinal (LV/RV GLS) and LV circumferential (GCS) strain and strain rates (SR) as well as left and right atrial reservoir/conduit/booster pump (LA/RA Es, Ee, Ea) strain and SR.
Results:
RV GLS was significantly reduced following PS compared to PR induction (PS -7.51 vs. PR -23.84, p< 0.001). RV GLS improved after induction of PR (before -20.50 vs. after -23.84, p=0.018) as opposed to PS (before -11.73 vs. after -7.51, p=0.128). Similarly, RA Es (PS 14.22 vs. PR 27.34, p=0.017) and Ee (PS 8.65 vs. PR 20.51, p=0.004) were decreased in PS compared to PR with detrimental impact of PS (Es before 23.20 vs. after 14.22, p=0.018, Ee before 15.04 vs. after 8.65, p=0.028) but not PR (Es before 31.65 vs. after 27.34, p=0.176, Ee before 20.63 vs. after 20.51, p=0.499).
Conclusion:
In a porcine model of RV pressure vs. volume overload, increased after- but not preload shows detrimental impact on RV and RA physiology.