.jpg "Damian Tyler, PhD photo")
Director of MR Physics
Oxford Centre for Magnetic Resonance Research, United Kingdom
Prof. Damian Tyler is the Director of MR Physics at the Oxford Centre for Clinical Magnetic Resonance Research (OCMR) and a British Heart Foundation Senior Research Fellow at the University of Oxford. He has been based in Oxford since 2001 and has 15 years experience in the development and application of Magnetic Resonance Imaging and Spectroscopy (MRI/MRS). He gained his MSci in Medical Physics in 1998 and his doctorate in 2001, both from the University of Nottingham.
Prof. Tyler's research in Oxford has been based on the study of cardiac structure, function and metabolism in normal and diseased hearts using MRI/MRS. This has included developing techniques using high spatial and temporal resolution CINE imaging to assess heart function and localized phosphorus and carbon spectroscopy to monitor and investigate abnormalities of metabolism. His recent research focus has been on the development and application of hyperpolarized MRI in the study of cardiac metabolism in the human heart. A fundamental limitation of magnetic resonance spectroscopy is its low sensitivity, but the recently developed technique of hyperpolarized MRI provides a practical method to gain up to 10,000-fold increases in sensitivity in molecules with an in vivo stability of approximately one minute. This has enabled visualization of 13C-labelled cellular metabolites in vivo and, more importantly, their enzymatic transformation into other species. This is an important development that could revolutionize spectroscopy using MR.
Wednesday, January 29, 2025
9:35 AM – 9:45 AM East Coast USA Time
