ISMRM - SCMR Workshop
Lu Zhang, MD
MD
West China Second University Hospital, China (People's Republic)
Yingkun Guo, PhD
Dr
West China Second University Hospital, China (People's Republic)
To explore the diabetes duration(DD) on left ventricular function and strain in children and adolescents with T1DM via cardiac magnetic resonance feature tracking (CMR-FT) technology.
Methods:
This study included 111 children and adolescents with T1DM, who were differentiated according to whether the duration of diabetes was < 5 years [T1DM(DD< 5Y, n = 45) and T1DM(DD≧5Y, n = 66), respectively], along with 76 age and sex matched healthy controls, all of whom underwent CMR examination. LV function parameters, global peak strain, global peak systolic strain rate (PSSR) and global peak diastolic strain rate (PDSR) were measured and compared among the three groups, including radial, circumferential and longitudinal. Multivariable linear regression analysis was used to examine the factors associated with LV global strain parameters in the children and adolescents with T1DM.
Results:
There is no significant difference in ejection fraction between diabetes and control groups (all p > 0.05). The GRPS, PSSR-radial, PSSR-longitudinal, PSSR-circumferential, and PDSR-circumferential of patients with T1DM(DD≧5Y) was significantly higher than that of healthy controls and patients with T1DM(DD< 5Y) (all p < 0.05). Multivariable linear regression analyses adjusting for confounders revealed that DD was independently associated with LV PSSR-circumferential and PSSR-longitudinal (β=-0.49 and -0.36, p</span>≤0.001 and 0.016, respectively), and HbA1c was associated with LV PSSR-radial and PDSR-circumferential (β=-0.315 and 0.271, p=0.018 and 0.041, respectively). The children and adolescents with T1DM may have a subclinical phase of LV hyperdynamic, implying a compensatory mechanism exists prior to the long-term deterioration of myocardial function. DD and HbA1c were the main influencing factor of the LV systolic and diastolic function in children and adolescents with T1DM.
Conclusion:
