Associate Professor
University of California, San Francisco
Dr. Roselle Abraham is director of the UCSF Hypertrophic Cardiomyopathy Center of Excellence (HCM-COE) at UCSF. Hypertrophic cardiomyopathy is the most common cardiac genetic disease with a prevalence of 1:200 world wide. The clinical presentation of HCM varies from asymptomatic to patients with heart requiring transplantation, atrial fibrilation, stroke and sudden cardiac death. Dr, Abraham evaluates and treats complex patients with hypertrophic cardiomyopathy with the goal of preventing complications and improving quality of life.
Dr. Abraham has established an HCM Resesarch Program with basic, translational and clinical components. The overall goal of the program is to understand the molecular cardiac phenotype of HCM, develop diagnostic tools and targeted therapies for HCM patients. Some of my areas of interest include
1. Multi-modality cardiac imaging (CMR, ECHO) for treatment planning and arrhythmia risk stratification
2. Investigation of cardiac metabolism by combining hyperpolarized 13C-MRI, metabolomics and basic studies in humans and experimental HCM models
3. Discover disease mechanisms and design rational pathophysiology-based therapies that prevent/arrest the cardiac HCM phenotype
4. Imaging of cardiac microvascular function (13NH3-PET/MR to undertand mechanisms whereby mutations in sarcomeric protein genes influence cardiac microvascular function
Thursday, January 30, 2025
4:50 PM - 5:00 PM East Coast USA Time
