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On-Demand Video

Oral Abstract

Late Breaking Clinical Trials

Age-Related Outcomes in CMR Versus CT-Guided TAVR: A Secondary Analysis of a Randomized Clinical Trial

Saturday, February 1, 2025
9:28 AM – 9:37 AM East Coast USA Time
Location: Diplomat Ballroom

    Presenting Author(s)

  • IL

    Ivan Lechner, MD, PhD

    Resident
    University Clinic of Internal Medicine III, Cardiology, Austria

    • Primary Author(s)

  • IL

    Ivan Lechner, MD, PhD

    Resident
    University Clinic of Internal Medicine III, Cardiology, Austria

    • Co-Author(s)

  • MR

    Martin Reindl, MD

    University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria

  • CT

    Christina Tiller, MD, PhD

    Resident
    University Clinic of Internal Medicine III, Cardiology, Austria

  • MH

    Magdalena Holzknecht, MD, PhD

    Resident
    University Clinic of Internal Medicine III, Cardiology, Austria

  • FO

    Fritz Oberhollenzer, MD

    Resident
    University Clinic of Internal Medicine III, Cardiology, Austria

  • AK

    Alex Kaser, MD

    Resident
    University Clinic of Internal Medicine III, Cardiology, Austria

  • RB

    Roland Binder, MD

    Head of Department
    Clinic for Internal Medicine II, Cardiology, Austria

  • GK

    Gert Klug, MD

    Head of Department
    Deparment of Internal Medicine, Austria

  • AM

    Agnes Mayr, MD

    University Clinic of Radiology, Medical University of Innsbruck, Austria

  • AB

    Axel Bauer, MD

    Head of Department
    University Clinic of Internal Medicine III, Cardiology, Austria

  • BM

    Bernhard Metzler, MD

    University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria

  • Sebastian Reinstadler, MD

    University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria

Background: Transcatheter aortic valve replacement (TAVR) is the treatment of choice for older patients with severe aortic stenosis and is expanding into younger age groups. Computed tomography (CT) is the gold standard for TAVR planning. Cardiac magnetic resonance (CMR) is an alternative imaging modality for TAVR guidance.  The aim of this study was to evaluate the impact of age on implantation success in patients undergoing CT- or CMR-guided TAVR.


Methods: This was a secondary analysis of the randomized TAVR-CMR clinical trial comparing TAVR planning by CT or CMR (NCT03831087). For this analysis, patients were categorized according to the median age (82 years). Implantation success, defined according to the Valve Academic Research Consortium-2 definition (absence of procedural mortality, correct positioning of a single prosthetic valve, and proper prosthetic valve performance), was compared at hospital discharge between age groups for each imaging strategy.


Results: A total of 267 patients (median age 82 [IQR 80-85] years, 50% female) underwent TAVR at two hospitals in Austria between September 2017 and December 2022. Implantation success was not significantly different between imaging strategies for patients ≤82 years (92% (CT group) vs. 95% (CMR group), p=0.524) and patients >82 years (89.4% (CT group) vs. 91.9% (CMR group), p=0.622). All-cause mortality at 6 months was not significantly different between imaging strategies for patients ≤82 years (4.8% (CT group) vs. 5.3% (CMR group), p=0.839) and >82 years (9.1% (CT group) vs. 12.9% (CMR group), p=0.490).


Conclusion: CMR-guided TAVR was associated with similar TAVR outcomes compared with CT-guided TAVR irrespective of age.