Cardiac Magnetic Resonance T2 Mapping Early Detects the Increased Myocardial Inflammatory Change in Experimental Diabetic Pigs (RF_FR_432)

To evaluate the histopathologic changes associated with DM such as myocardial inflammatory and edema and validate the T2 values acquired using T2 mapping CMR against histopathologic features.



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Eleven diabetes pig models were generated by administering streptozotocin (150 mg/kg, intravenous injection). Three controls were age and weight matched healthy pigs. CMR T2 mapping was performed with a 3.0T scanner to evaluate global T2 in left ventricular. For histological analysis, the correlation between myocardial alterations under microscope and global T2 following hematoxylin-eosin (HE) staining investigations.



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Compared to controls, diabetes pigs showed similar T2 value at baseline (p ＞0.05) but increased from 2-month to 16-month post-modeling (all p < 0.05). In the subgroup analysis of diabetes pigs, compared to baseline (37.5±2.9 ms), T2 value was greater at 2 months (44.4±5.1 ms, p > 0.001) and 6 months post-modeling (44.5±6.7 ms, p = 0.03) and maintained an upward trend at 10 months (42.3±3.6 ms, p = 0.057) and 16 months (43.9±3.9 ms, p = 0.066). Furthermore, T2 value was associated with fasting blood glucose (r = 0.56, p = 0.02) and HbA1c (r = 0.67, p = 0.01). Both the inflammation score and the edema score obtained from HE staining exhibited significant relationships with T2 value (r = 0.587, p = 0.0187；r = 0.507, p = 0.04) .




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