ISMRM - SCMR Workshop
Wenqi Liu, BMSc
student
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), China (People's Republic)
Wenqi Liu, BMSc
student
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), China (People's Republic)
Jingjing Shi, MD
Resident doctor
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), China (People's Republic)
Wanzhen Li, BMSc
student
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), China (People's Republic)
Yiyuan Gao, MD
Resident doctor
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), China (People's Republic)
Maosheng Xu, PhD
Professor and Chairman
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), China (People's Republic)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) may manifest left or biventricular involvement, which has parallels with dilated cardiomyopathy (DCM) in advanced stage. Cardiac magnetic resonance-feature tracking (CMR-FT) are desirable to evaluate right atrial (RA) strain and strain rate, thus assessing the difference in RA functional variations between ARVC and DCM.
Methods: This study retrospectively included 38 patients with ARVC, 98 patients with DCM and 72 healthy controls. RA strain parameters, including RA reservoir, conduit, booster strain (εs, εe, and εa) and peak positive, peak early negative, and peak late negative strain rate (SRs, SRe, and SRa), were assessed using CMR-FT. One-way ANOVA were used for comparisons of RA strain parameters among three groups. Reproducibility of CMR-FT derived RA strain parameters were assessed by interclass correlation coefficient (ICC) and Bland-Altman analysis. Receiver operating characteristic (ROC) analysis was used to assess differential diagnostic values of RA strain parameters between ARVC and DCM.
Results: RA εs, εe, SRs, and SRe in ARVC patients were deceased compared with healthy controls (all P < 0.05), while RA εs, εe, εa, SRs, SRe, and SRa in DCM patients were lower than those of ARVC and healthy controls (all P</em> < 0.05). ICC and Bland-Altman analysis demonstrated excellent reproducibility of CMR-FT-derived RA strain and strain rate (all ICC > 0.80). ROC curve showed that RA strain parameters especially RA conduit strain manifested supportive differential diagnostic value between ARVC and DCM (AUC=0.791).
Conclusion: Both ARVC and DCM patients exhibited impaired RA phasic function, with DCM patients demonstrating lower values than those with ARVC. RA strain parameters may help in discriminating ARVC and DCM as a potential diagnostic indicator.
